Request PDF on ResearchGate | Dermatitis granulomatosa intersticial con artritis | —Interstitial granulomatous dermatitis with arthritis is a systemic disease. La dermatitis granulomatosa intersticial con artritis es una enfermedad sistémica que afecta a la piel y al sistema musculosquelético. Esta nueva entidad se. Summary. An Orphanet summary for this disease is currently under development. However, other data related to the disease are accessible from the Additional.

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Papules, annular plaques and erythematous-purplish infiltrated nodules on medial surface of left thigh.

Dermatitis; Granulomatous disease, chronic; Thyroiditis; Thyroiditis, autoimmune. The lack of randomized clinical studies has prevented an optimal treatment for IGD to be determined.

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The typical microscopic presentation should be that of a granulomatous dermatitis, with palisading or interstitial histiocytes, variable numbers of neutrophils and eosinophils, and scattered areas of degenerating collagen bundles. Egas Moniz Lisboa, Portugal E-mail: At the histopathological examination, infiltration of reticular dermis was observed with predominance of interstitial and palisaded histiocytes and some areas of collagenous degeneration, associated with a lower number of neutrophils and eosinophils.

Clues to intersficial in dermatopathology. Clin Rheumatol Interstitial granulomatous dermatitis and paraneoplastic rheumatoid polyarthritis disclosing cancer of the lung.

Dermatitis granulomatosa intersticial en placas con artritis en una adolescente: Informe de un caso

Biopsy examination of a skin specimen showed findings of early interstitial granulomatous dermatitis. The patient was treated with hydroxicloroquine with partial response.


It presents as annular plaques on the arms, medial thighs and skin folds.

How to cite this article: For all other comments, please send your remarks via contact us. The features of interstitial granulomatous dermatitis are variable. Subscriber If you already have your login data, please click here.

Services on Demand Article. Subscribe to our Newsletter. A year-old female presented with recurrent, widespread, erythematous, painful plaques, over a 3-month period. Histologically, a diffuse interstitial infiltrate with histiocytes and foci of collagen degeneration is seen, as well as the formation of small granulomas around these areas of degeneration.

Additional investigation revealed hypothyroidism and positive anti-thyroid antibodies. Palisading neutrophilic granulomatous dermatitis is diagnosed on skin biopsy. Therefore, dermatologists should be aware of this possibility, since they are in a privileged position to diagnose potentially life-threatening diseases, at an early stage.

There is less information about associations with palisading neutrophilic granulomatous dermatitis. Although the original manifestation had been described as subcutaneous linear nodules, also known as rope sign 1later reports showed a clinical spectrum quite heterogeneous which vary from hyperpigmented, erythematous papules, subcutaneous plaques, annular lesions to firm red-purplish nodules as observed in our patient. A disorder associated with autoantibodies.

Dermatologists should be alert to this diagnostic possibility, for they are dwrmatitis in a privileged position when monitoring these patients. A year-old Caucasian female presented to the emergency room with 2 erythematous, sharply demarcated, painful, indurated plaques, on her left arm and right thigh, which had appeared in the previous 48 hours.


Papules, annular plaques and erythematous-purplish infiltrated nodules on medial surface of right thigh.

Granulomatous dermatitis

It is thought to be a distinct clinical and pathological entity. When reevaluted, after 1 week, those lesions had resolved, but 2 new similar plaques had appeared over the right arm and left buttock, and linearly arranged erythematous papules had arisen on the right hand Figure 1.

Interstitial granulomatous dermatitis is a histologic inflammatory reaction, with variable cutaneous expression. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Normal epidermis for this site, without basal cell vacuolar degeneration.

The characteristic histological features of palisading neutrophilic granulomatous dermatitis are:. The histopathological examination defines the diagnosis characterized as dense and diffuse interstitial infiltrate in the reticular dermis, composed of histiocytes in a palisade arrangement, sometimes with necrobiosis of collagen and involved by inhersticial neutrophils and eosinophils.

RA, diagnosed 10 years ago with symmetrical deforming polyarthritis of the small-joints of hands and being monitored by the Rheumatology Service of HSPE-SP; systemic arterial hypertension and obesity.